In Stick with Me, Izzy and Wren, two very different 12-year-olds are unwittingly brought together at just the right time in their lives. Izzy, a sweet, creative artist with a love for stickers lives in Boston with her parents and older brother Nate. Her best friend, Phoebe is now friends with popular, not-so-nice girl, Daphne, and only hangs out with Izzy because their mothers who are best friends, make them. Wren, on the other hand, is a determined figure skater whose little sister, Hannah has epilepsy.