In No Vacancy, Miriam Brockman’s family — who are Jewish — has just moved into a motel they bought in upstate New York. On top of the change from city to small town, Miriam has to work with her parents and uncle (who comes to help) to renovate the motel. Her parents are also struggling because the motel is in poor financial state, contrary to what the sellers had initially told them. This jeopardizes their plan to renovate and then sell the motel so they can buy a home.
Next door to the hotel is a diner owned by a Catholic elderly couple, whose granddaughter, Kate, befriends Miriam. Miriam also begins working at the diner, peeling grapes for grape pie. In a bid to help draw customers to the motel, both girls create the illusion of a Virgin Mary apparition in a local abandoned drive-in. Their plan works, and customers start flooding the motel, but Miriam can’t shake the guilt, even as she explores other questions about religion and disability.